Glucoraphanin cas 21414-41-5 anti-inflammatory
Glucoraphanin Biological Activity
|Description||Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.|
Signaling Pathways >> Others >> Others
|In Vivo||Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2−/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2−/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice.|
|Animal Admin||Male C57BL/6JSlc mice are 7 weeks of age. The Nrf2 knockout (Nrf2−/−) mouse strain is used in the assay. After 1 week of acclimation, mice are fed normal chow (NC) (containing 2.2% dextrinized cornstarch, 10% kcal from fat), NC containing 0.3% glucoraphanin (NC-GR) (containing 2.2% extract powder), an HFD (containing 2.2% dextrinized cornstarch, 60% kcal from fat), or an HFD containing 0.3% glucoraphanin (HFD-GR) (containing 2.2% extract powder) for 14 weeks. Both the NC and the HFD containing cornstarch or glucoraphanin are prepared. All mice studied are maintained on a 12-h light/dark cycle at 24-26°C with free access to water and food.|
Contact Us: luly Whatsapp:+8613073165382 Email:firstname.lastname@example.org Q1: Have your Product Quality been Approved by Third Party Lab? A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. Q2:How do you treat quality complaint? A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss. Q3: Do you Accept Sample Order? A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods. Q4: Is there any discount? A: Yes, for larger quantity, we always support with better price. Q5:what payment terms do you accept ? A:we’d like to accept bank transfer, Western Union or Moneygram or BTC Q6:How long does it take to the goods arrived ? A:It is Depending on your location, For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea. Q7 Do you have any reshipment policy ? A： we have good after-sale service and re-shipment policy if the parcel lose Our long association with our clients has brought great benefits We always take the upmost care in the packaging of our products our clients will confirm this as even they struggle to find them without help at times. But in spite of our best efforts it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish long term relationship Q8 :Can I get a sample? A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.